Our lab’s research investigates how the brain flexibly encodes, maintains, and updates sensory and internal representations to support adaptive behavior.
01
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How is a sequence of neural activity maintained over time?
We investigate how cortical and thalamocortical circuits sustain transient activity patterns to support short-term memory and internally guided behaviors. Using in vivo recordings and perturbation techniques, we explore the cellular and synaptic mechanisms that stabilize sequential dynamics across brain regions.
02
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How is a sequence appropriately terminated?
Not all information needs to be held indefinitely. We study how neural circuits signal when to stop or reset ongoing internal processes, with a focus on inhibitory control, network deactivation, and task-dependent transitions. These dynamics are critical for understanding flexible behavior and cognitive boundaries.
03
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How does multisensory perception integrate—and sometimes interfere with—prediction?
Our lab examines how information from different sensory modalities is combined in the cortex, and how these signals interact with prior expectations. We are particularly interested in how this integration supports accurate perception—and how mismatches may lead to perceptual errors, including in neuropsychiatric models.
04
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How are these functions altered in schizophrenia?
We are investigating how the mechanisms underlying sequential activity, termination control, and multisensory integration are disrupted in schizophrenia mouse models. Our goal is to understand how deficits in short-term memory and sensory perception arise from circuit-level changes in the cortex and its thalamic partners.
